Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Severe obesity is associated with suppressed expression of both ApN and its receptors in both SAT and VAT, the expression levels in VAT are specifically linked with hyperinsulinemia and dyslipidemia.
|
17607322 |
2007 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin and decreased adiponectin levels along with endothelial dysfunction are present in normotensive subjects with FT. IR and hypoadiponectinemia are interrelated, but only hyperinsulinemia has an independent adverse influence on endothelial function.
|
23822941 |
2013 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Insulin increased adiponectin expression specifically in the omental tissue (P = 0.011).
|
18208577 |
2008 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, these rats showed hyperinsulinemia, decreased insulin sensitivity, increased insulin resistance, down-regulated mRNA levels of adiponectin receptors in inguinal white adipose tissue (Adipor1 and Adipor2) and soleus muscle (Adipor2), and decreased levels of phosphorylated AMPK, the downstream post-receptor target of adiponectin, in the soleus muscle.
|
28974704 |
2017 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expressions of both resistin and adiponectin in s.c. adipose tissue are stimulated by acute hyperinsulinaemia, whereas losartan attenuates their insulin-stimulated expressions.
|
17893258 |
2007 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin as well as HOMA-IR levels and decreased adiponectin levels were found in VPA treated subjects when compared to the newly diagnosed patients.
|
29906708 |
2018 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that increased SBP, DBP and resting HR as well as increased insulin and resistin plasma levels and decreased adiponectin plasma levels pre-exist in young healthy offspring with positive family history for essential hypertension.
|
18568692 |
2008 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, CT KO mice exhibited significantly decreased fat contents in the liver, lipid droplets in adipose tissues, serum glucose, and lipid levels, and significantly increased insulin sensitivity and serum adiponectin levels.
|
30451912 |
2018 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin is a hormone secreted by the adipose tissue, and serum levels are inversely correlated with obesity and hyperinsulinemia.
|
18827209 |
2008 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Subsequently, in vitro studies in 3T3-L1 (white) and T37i (brown) adipocytes suggest that the increased leptin and adiponectin levels were mainly driven by the elevated insulin levels.
|
31265057 |
2019 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The observed association between higher adiponectin levels and increased insulin sensitivity is likely to represent a causal relationship partly mediated by reduced adiposity.
|
23274890 |
2013 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
When the data were analyzed by adiponectin tertiles, an elevated adiponectin level was associated with high total, oxidative, and nonoxidative glucose disposal and high energy expenditure during hyperinsulinemia; low levels of free fatty acids and low rates of lipid oxidation during hyperinsulinemia; as well as low levels of inflammatory cytokines; and a low amount of intraabdominal fat evaluated by computed tomography.
|
15855264 |
2005 |
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
GE treated groups improved the glucose tolerance, attenuated hyperglycemia and hyperinsulinemia in the mice by up-regulating the adiponectin and GLUT-4 gene expressions.
|
23259700 |
2012 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resistance training had no effect on the plasma adiponectin response to hyperinsulinemia.
|
29412474 |
2018 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adiponectin, an adipose tissue-derived hormone, exhibits anti-inflammatory properties and has various biological functions, such as increasing insulin sensitivity, reducing hypertension, and suppressing atherosclerosis, liver fibrosis, and tumor growth.
|
16952554 |
2006 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Expression of AdipoR isoforms can be regulated by hyperinsulinaemia and hyperglycaemia with the consequence of increased sensitivity or resistance to specific forms of adiponectin.
|
17052201 |
2006 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
RGD |
Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
|
16414018 |
2006 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, high adiponectin predicts increased insulin sensitivity.
|
12540592 |
2003 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
These changes were associated with reductions in NO and adiponectin bioavailability, and rescued by exogenous adiponectin or hyperinsulinemia.
|
30006585 |
2019 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the chronic experiment, nutraceuticals did not alter body weight or glycemic control, but improved fed hyperinsulinemia (mean difference = 30.80 mU/L, <i>p</i> = 0.044) and homeostatic model assessment-insulin resistance (HOMA-IR) (mean difference = 15.29, <i>p</i> = 0.033), and plasma adiponectin levels (mean difference = -0.99 µg/mL, <i>p</i> = 0.048).
|
29271886 |
2017 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
The following biomarkers were assessed in plasma samples donated by chronic disease-free women (1990) and men (1994): C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α receptor 2 (TNFαR2) and adiponectin for inflammation; estrone and estradiol for hormonal response in women, C-peptide for hyperinsulinemia; and triglycerides/high density lipoprotein-cholesterol (TG/HDL) ratio for insulin resistance.
|
27798951 |
2017 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adiponectin stimulates fatty acids oxidation, decreases plasma triglycerides, and improves glucose metabolism by increasing insulin sensitivity.
|
12601307 |
2003 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity.
|
22996660 |
2012 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Low plasma adiponectin concentration independently predicted future abdominal visceral fat accumulation and increased insulin resistance in Japanese Americans.
|
29029184 |
2017 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
BEFREE |
Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.
|
29494595 |
2018 |